REDR1998 Reproduction in Domestic Ruminants IV Local Cellular and Tissue Communication (4 abstracts)
Plasmin–tumour necrosis factor interaction in the ovulatory process
WJ Murdoch
Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA
Collagen breakdown and apoptotic cell death within the apex of the preovulatory ovine follicle are hallmarks of impending ovarian rupture. An integrative mechanism is proposed whereby gonadotrophic stimulation of urokinase-type plasminogen activator secretion by the follicular-contiguous ovarian surface epithelium elicits a localized increase in tissue plasmin, which activates collagenolysis and tumour necrosis factor α-induced cell death within the formative ovulatory stigma.
© 1999 Journals of Reproduction and Fertility Ltd
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