REDR2002 Reproduction in Domestic Ruminants V Ruminant Models for Human Clinical Medicine (5 abstracts)
Reprogramming the genome: role of the cell cycle
KHS Campbell & R Alberio
University of Nottingham, School of Biosciences, Sutton Bonington, Loughbrough, Leicestershire LE12 5RD, UK
In nuclear transfer reconstructed embryos, the co-ordination of donor nuclear and recipient cytoplasmic cell cycle phases is essential to maintain ploidy and prevent DNA damage. However, the stage of the cell cycle at the time of reconstruction and the method of reconstruction may also have a significant impact on the subsequent development of the embryo and fetus through a number of other mechanisms. This paper reviews some of the information currently available and proposes that consideration of the cell cycle may lead to improvement of methods for embryo reconstruction.
© 2003 Society for Reproduction and Fertility
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