Functional analysis of autocrine and paracrine signalling at the uterine–conceptus interface in pigs

L. A.  Jaeger; L. A.  Johnson; H.  Ka; J. G. Gadow; R. C. Burghardt; T. E. Spencer; F.W.  Bazer

doi:10.1530/biosciprocs.16.0014

CPR14

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Bioscientifica Proceedings (2020) 16 CPRCPR14 | DOI: 10.1530/biosciprocs.16.0014

CPR2001 Control of Pig Reproduction VI Embryonic and Placental Development (3 abstracts)

Functional analysis of autocrine and paracrine signalling at the uterine–conceptus interface in pigs

L. A. Jaeger ^1,2 , G. A. Johnson ^2,3* , H. Ka ^2,3 , J. G. Gadow ^2,3 , R. C. Burghardt ^1,2 & T. E. Spencer ^{2,3 and F.W. Bazer}

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¹Department of Veterinary Anatomy & Public Health, College of Veterinary Medicine, ²Center for Animal Biotechnology and Cenomics, and ³Department of Animal Science, Texas A&M University, College Station, TX 77843-44S8, USA

The complexity of implantation necessitates intimate dialogue between conceptus and maternal cells, and precise coordination of maternal and conceptus signalling events. Maternal and conceptus-derived steroid hormones, growth factors and cytokines, as well as integrins and their ligands, have important and inter-related roles in mediating adhesion between apical aspects of conceptus trophectoderm and maternal uterine luminal epithelium that leads to formation of an epitheliochorial placenta. lntegrin receptors appear to play fundamental roles in the implantation cascade and may interact with extracellular matrix molecules and other ligands to transduce cellular signals through autocrine and paracrine mechanisms. Functional in vitro analyses can be used to monitor individual contributions of specific integrin receptors and ligands to the signalling cascades of the maternal-conceptus interface. Integrative studies of implantation in pigs, using in vivo and in vitro approaches, are required to understand conceptus attachment and implantation in this species, and provide valuable opportunities to understand the fundamental mechanisms of implantation in all species.

Volume 16

Control of Pig Reproduction VI

Society for Reproduction and Fertility

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CPR14

Functional analysis of autocrine and paracrine signalling at the uterine–conceptus interface in pigs

L. A. Jaeger 1,2 , G. A. Johnson 2,3* , H. Ka 2,3 , J. G. Gadow 2,3 , R. C. Burghardt 1,2 & T. E. Spencer 2,3 and F.W. Bazer

Volume 16

Control of Pig Reproduction VI

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Jaeger L. A.

Johnson L. A.

Ka H.

Gadow J. G.

Burghardt R. C.

Spencer T. E.

Bazer F.W.

BiosciAbstracts

L. A. Jaeger ^1,2 , G. A. Johnson ^2,3* , H. Ka ^2,3 , J. G. Gadow ^2,3 , R. C. Burghardt ^1,2 & T. E. Spencer ^{2,3 and F.W. Bazer}