Bioscientifica Proceedings

This review focuses on factors that may affect the sensitivity of the corpus luteum to uterine prostaglandin F_2α, (PGF_2α) and embryonic signals. The heterogeneity of the types of cell that are present within the corpus luteum results in complex interactions that ensure complete luteal regression in response to PGF_2α. There is not likely to be a single factor that determines responsiveness. The sensitivity of the corpus luteum depends on the proper balance of a variety of factors that are involved in mediating the effects of PGF_2α. This balance is achieved as the early corpus luteum undergoes development, but may also be altered by embryonic factors to rescue the corpus luteum during early pregnancy.

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