REDR2014 Reproduction in Domestic Ruminants VIII Placentation/Parturition (3 abstracts)
Early placentation and local immune regulation
Kazuhiko Imakawa 1* , Kazuya Kusama 1 , & Jiro Yasuda 2
1Laboratory of Theriogenology and Animal Breeding, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan; 2Departmernt of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
Abstract. It was once thought that processes of conceptus implantation and placentation vary among mammalian species. However, physiological and biochemical processes including gene expression show more similarities than differences. In fact, recent progress has identified that in addition to the hormones, cytokines, proteases and cell adhesion molecules classically characterized, epithelial-mesenchymal transition (EMT), epigenetic regulation and the expression of endogenous retroviruses (ERV) are all required for the progression of conceptus implantation to placentation. Thus, continued research into EMT, epigenetic regulation, the expression of ERVs and immunoregulatory systems will aid in enhancing understanding of their impact on reproductive physiology in humans and domestic animals.
© 2014 Society for Reproduction and Fertility
Volume 8
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