Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0018cpr37 | State-of-The Art in Conceptus-Uterus Interactions/Early Pregnancy Signaling | CPR2009

Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptuses

Johnson G.A. , Bazer F.W. , Burghardt R.C. , Spencer T.E. , Wu G. , Bayless K.J.

This review highlights information on conceptus-uterus interactions in the pig with respect to uterine gene expression in response to estrogens and interferons (IF Ns) secreted from elongating conceptuses. Pig conceptuses release estrogens for pregnancy recognition, but also secrete IENs that do not appear to be antiluteolytic. Estrogens and IFNs induce expression of largely non-overlapping sets of genes, and evidence suggests that pig conceptuses orchestrate essential e...

bp0004rdr25 | Embryonic Survival | REDR1998

Mechanism of action of interferon-tau in the uterus during early pregnancy

Hansen TR , Austin KJ , Perry DJ , Pru JK , Teixeira MG , Johnson GA

Early pregnancy is maintained in ruminants through the actions of conceptus-derived interferon (IFN)-tau on the endometrium. IFN-tau alters uterine release of PGF2α, which results in rescue of the corpus luteum and continued release of progesterone. The mechanism of action of IFN-tau includes inhibition of oestradiol receptors, consequent reduction in oxytocin receptors, activation of a cyclooxygenase inhibitor, and a shift in the PGs to favour PGE2 ...