Bioscientifica Proceedings

The focus of this review is the physiological effects of undemutrition on ovarian follicle growth and the occurrence of ovulation in postpartum cows. Evidence suggests that moderate levels of underfeeding, before or after calving, may interfere with the mechanism(s) of final follicle maturation and ovulation, whereas more pronounced nutritional deficiencies may affect the mechanism(s) regulating dominant follicle size and the dynamics of dominant follicle growth and regression...

Abstract unavailable© 1995 Journals of Reproduction and Fertility Ltd ...

In several ungulate species, the preimplantation trophoblast, among various secretions, produces large amounts of antiviral activity that was identified as interferon (IFN). IFNs (types I and II) are pleiotropic cytokines, which in addition to a potent antiviral activity, exert multiple effects on cell growth and differentiation, in particular on the cells of the immune system. In ruminants, trophoblastic IFN, or trophoblast protein-1 (TF-1), was found to consist of a mul...

Summary. Primary cultures of ovine epithelial and stromal cells have been used to examine paracrine interactions between the endometrium and the preimplantation sheep blastocyst, and in particular the actions of the blastocyst α-interferon, ovine trophoblast protein-1 (oTP-1), on endometrial cell metabolism. The synthesis and secretion of several ‘pregnancy-related’ acidic proteins with molecular weights in the range 70 000–120 000 can be i...

Trophoblast invasiveness in ruminants is limited to fusion of migrating binucleate cells with uterine epithelium, but considerable tissue remodelling and angiogenesis occurs within the endometrium at implantation. Such processes are elsewhere associated with an altered balance of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). ProMMPs-1, -2, -3 are secreted by cultured ovine endometrial stromal, but not epithelial, cells and expression of proMMP-1 and pro...

This article reviews experiments performed to investigate the importance of thyroid hormones to the expression of the seasonal reproductive cycle of ewes. Thyroidectomy was found to block the transition from the breeding season to anoestrus and to cause ewes to exhibit oestrous cycles all year round. Mechanistically, thyroidectomy produced this effect by preventing the seasonal increase in responsiveness to the negative feedback action of oestradiol on episodic GnRH secretion,...

Early follicular growth refers to the development of an ovarian follicle from the primordial to early antral phase. In sheep and cows these phases of growth can be classified by the configuration of granulosal cells in the largest cross–section of the follicle as types 1 (primordial), la (transitory) 2 (primary), 3 and 4 (preantral) and 5 (early antral). Follicles classified as type 1 may be highly variable within each species with respect to number of granulosal cells an...