Bioscientifica Proceedings

Conceptus development in mammals depends on an intra-uterine environment filled with histotroph that includes molecules that are secreted by uterine epithelia and/or selectively transported into the uterine lumen. In pigs, total recoverable glucose, fructose, arginine, leucine and glutamine increase in histotroph with advancing days of the peri-implantation period of pregnancy and in allantoic fluid later in gestation. During pregnancy, the uterine luminal epithelium (LE...

In swine and other livestock, the uterine endometrium exhibits dramatic morphological and secretory changes throughout the oestrous cycle and during pregnancy. Such physiological changes are a reflection of extremely complex interactions between gene products (RNA and protein). The recent development of genomics and proteomics methods, as well as associated bioinformatics tools, has provided the means to begin characterising such interactions. Indeed, the analysis of the...

Next generation sequencing platforms have democratized genome sequencing. Large genome centers are no longer required to produce genome sequences costing millions. A few lanes of paired-end sequence on an lllumina Genome Analyzer, costing <$10,000, will produce more sequence than generated only a few years ago to produce the human and cow assemblies. The de novo assembly of large numbers of short reads into a high-quality whole-genome sequence is now technical...