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bp0008rdr16 | Challenges in Optimization of Reproductive Performance | REDR2014

Endocrine disruptors and ovine reproductive development

Lea Richard G , Byers Andrew S , Bellingham Michelle , Cotinot Corinne , Evans Neil , Mandon-Pepin Beatrice , Sinclair Kevin D , Fowler Paul A

Summary. Declining fertility and perturbations in reproductive development in a variety of species have been linked to exposure to endocrine disrupting chemicals (EDCs), which are ubiquitous in the environment. Ruminants are largely exposed to such chemicals in sewage sludge fertiliser widely used in animal production systems. This has been investigated experimentally through the deliberate exposure of pregnant ewes to sewage sludge fertilised pastures or cont...

bp0008rdr32 | Emerging Reproductive Technology | REDR2014

Inducing pluripotency in livestock somatic cells to enhance genome-editing opportunities

Liu Jun , Taheri-Ghahfarokhi Amir , Verma Paul John

Abstract. Although the manipulation of animal genomes has a history of more than three decades, there are only a few of the reported genetically modified (GM) animals that have passed safety regulations and found their way through to market. The production and safety regulations of GM livestock are hindered by a variety of issues, most importantly, lack of embryonic stem cells (ESC) in livestock species and concerns around the nature and biosafety of the genom...