Bioscientifica Proceedings

Abstract unavailable© 1995 Journals of Reproduction and Fertility Ltd...

Structural patterning and functional programming of uterine tissues are mechanistically coupled. These processes ensure anteroposterior differentiation of uterine tissues from adjacent segments of the developing female reproductive tract (FRT) and radial patterning that establishes uterine-specific histoarchitecture and functionality. Uterine organogenesis begins prenatally and is completed postnatally. Genes required for FRT development include Pax2, Lim 1<...

Uterine differentiation in cattle and sheep begins prenatally, but is completed postnatally. Mechanisms regulating this process are not well defined. However, studies of urogenital tract development in murine systems, particularly those involving tissue recombination and targeted gene mutation, indicate that the ideal uterine organizational programme evolves epigenetically through dynamic cell–cell and cell–matrix interactions that define the microenvironmental conte...

Summary. Microbes commonly infect the female genital tract of cattle, causing uterine disease, abortion, and infertility. In particular, postpartum uterine disease develops in about 40% of dairy cows following infections with Gram-negative Escherichia coli and Gram-positive bacteria, such as Trueperella pyogenes. These infections damage tissues and cause inflammation in the endometrium, and perturb follicle growth and function in the ovar...

Advances in the analyses of human and other higher eukaryotic genomes have disclosed a large fraction of the genetic material (ca 98%) which does not code for proteins. Major portion of this non-coding genome is in fact transcribed into an enormous repertoire of functional non coding RNA molecules (ncRNAs) rather than encoding any proteins. Recent fascinating and fast progress in bioinformatic, high-throughput sequencing and other biochemical approaches have fuelled rapid ...