Bioscientifica Proceedings

Regulation of gonadotrophin synthesis involves a complex interaction between hypothalamic and gonadal hormones. Chronic administration of oestrogens and androgens to gonadectomized animals blocked the postcastration rise in amounts of mRNA encoding gonadotrophin subunits. Removal of endogenous GnRH decreased amounts of mRNA encoding gonadotrophin subunits. Pulsatile administration of GnRH to GnRH-deficient animals increased amounts of mRNA encoding gonadotrophin subunits. Stud...