Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0002rdr1 | Maternal Recognition of Pregnancy | REDR1990

The polypeptides and genes for ovine and bovine trophoblast protein-1

Roberts RM , Klemann SW , Leaman DW , Bixby JA , JA Cross JC , Farin CE , Imakawa K , Hansen TR

Summary. Ovine and bovine trophoblast protein-1 (oTP-1 and bTP-1) have been strongly implicated as antiluteolytic agents and responsible for maternal recognition of pregnancy in sheep and cattle, respectively. Both are interferons (IFN) belonging to the IFN-α family, but their length (172 residues versus 166 for most IFN-α) places them in an unusual subclass (the IFN-αII). The various isoforms of oTP-1 and bTP-1 produced by trophoblas...

bp0019cpr6 | Oocyte-embryo Interplay with in vitro or in vivo milieu | CPR2013

Transcriptional profiling of oocyte maturation and embryonic development elucidates metabolism and control of development

Prather Randall S. , Brown Alana , Spate Lee D. , Redel Bethany K. , Whitworth Kristin M. , Whyte Jeffrey J.

With the advent of next generation sequencing platforms (RNA-seq), transcriptional profiling permits the characterization of millions of RNAs from even the most limiting samples like early embryos. High-throughput RNA-seq can generate over 600 gigabases (Gb) in a single sequencing run, providing a near-complete record of all of the genes expressed in a sample at the time of collection. Condensing and finding coherence in the immense amount of raw data generated by transc...

bp0005rdr19 | Ovary-Uterus-Embryo Interactions | REDR2002

Regulation of embryo survival in cattle

Thatcher WW , Guzeloglu A , Meikle A , Kamimura S , Bilby T , Kowalski AA , Badinga L , Pershing R , Bartolome J , Santos JEP

Evidence is presented that bovine somatotrophin (bST) treatment of lactating dairy cows enhances both expression of oviductal insulin-like growth factor II (IGF-II) mRNA and endometrial insulin-like growth factor binding protein 3 (IGFBP-3) mRNA between day 3 and day 7 of the oestrous cycle. mRNA encoding growth hormone (GH) receptor in endometrial tissues increased between day 3 and day 7 of the oestrous cycle. The changes induced by bST treatment may contribute to stimulatio...

bp0005rdr32 | Ruminant Models for Human Clinical Medicine | REDR2002

Domestic ruminants as models for the elucidation of the mechanisms controlling ovarian follicle development in humans

Campbell BK , Souza C , Gong J , Webb R , Kendall N , Marsters P , Robinson G , Mitchell A , Telfer EE , Baird DT

It is necessary to understand the basic physiology underlying the complex process of folliculogenesis to address common causes of infertility and to devise innovative strategies to increase the efficiency of assisted reproduction technologies. Availability of suitable ovarian tissue is a major constraint to research in this area in humans, and monovulatory domestic ruminants represent a physiologically relevant model to elucidate basic mechanisms before more focused clinical i...

bp0014cpr8 | Ovarian and Uterine Function | CPR1993

The role of insulin-like growth factors and epidermal growth factor-related peptides in intraovarianregulation in the pig ovary

Hammond J. M. , Samaras S. E. , Grimes R. , Leighton J. , Barber J. , Canning S. F. , Guthrie H. D. ,

The autocrine and paracrine role of the insulin-like growth factors (IGFs) and epiderrnal growth factor (EGF)-related peptides in pig ovary are reviewed. For convenience, each of these regulatory systems is divided into several interactive components: regulated expression of the growth factors, growth factor reception at the cell surface and intracellular action of the growth factors. In addition, the concept of regulated bioavailability and targeting of growth factors in...

bp0016cpr4 | Development of The Follicleand Corpus Luteum | CPR2001

Formation and early development of the corpus luteum in pigs

Murphy B. D. , Gévry N. , Ruiz-Cortés T. , Cote F. , Downey B. R. , Sirois J.

Numerous corpora lutea form from the multiple follicles that ovulate during the oestrous cycle of pigs. Vascular elements invade the follicle from the theca compartment, first centripetally, and subsequently by lateral branching of centripetal veins and arteries. The vessels are the vehicle for dispersion of steroidogenic theca cells throughout the corpus luteum. Mitosis occurs in both the theca and granulosa layers before ovulation, and in luteal cells well into the lut...