Bioscientifica Proceedings

Geneticists have made limited progress in improving reproductive traits in pigs through traditional selection and crossbreeding systems. Recent advances in molecular genetics and the human genome project have allowed progress in gene identification and gene mapping in pigs. The pig genetic linkage map now has over 1700 genetic markers, and about 200 of these are genes. Furthermore, comparative genomic maps are improving and are becoming useful tools. Molecular approaches ...

Recent publication of the sequence of the pig genome allows for faster and more accurate selection for traits expressed late in life, sex limited or difficult to measure. Especially reproduction and adaptation traits fall in this category. Existing genetic variation in reproduction traits is substantial and polygenic selection has resulted in genetic trend of around half a piglet per sow per year. A very significant increase in genetic trend is anticipated through genomi...

Bone morphogenetic proteins (BMPs) represent the largest subclass of growth factors in the transforming growth factor ß (TGF-ß) superfamily. BMPs have proven to be multifunctional regulators of a wide variety of biological processes in numerous types of cell and tissue. The role of inhibins, activins and TGF-ßs (which also belong to the TGF-ß superfamily) in reproduction has been studied extensively over the last 15 years. However, there were no reports on ...

Endogenous retroviruses (ERVs) are present in the genome of all vertebrates and are remnants of ancient exogenous retroviral infections of the host germline transmitted vertically from generation to generation. Sheep betaretroviruses offer a unique model system to study the complex interaction between retroviruses and their host. The sheep genome contains 27 endogenous betaretroviruses (enJSRVs) related to the exogenous and pathogenic Jaagsiekte sheep retrovirus (JSRV), the ca...

During embryonic diapause, the development of the embryo is paused shortly after conception by metabolic or seasonal factors. When conditions become favorable, the embryo will resume development after reactivation by the maternal reproductive system. Inducing this resting state in in vivo or in vitro manipulated embryos may offer invaluable advantages in the long-term storage of embryos, therefore offering a potential worthwhile and novel alternative in assisted reproduction c...

Summary. Important improvements in the management of sows have been made over the past 20 years in Europe and the U.S.A. Nevertheless, annual productivity varied between 15 and 25 piglets weaned per sow per year in France for 1983. Reasons for such a difference in productivity have been analysed quantitatively.Marked differences exist between herds in the genotype of pig used and in the age of puberty. Transportation acts as a stress...

The pig industry is confronted with substantial losses due to piglet mortality. With 3-8% stillbirths and generally > 10% preweaning mortality, approximately one fifth of al I fetuses formed fully at the end of gestation die before weaning. Most of these losses occur in the perinatal period. Overall prenatal development (birth weight) and specific prenatal developmental and maturational processes in late gestation are predisposing factors for perinatal losses. Birth weight ...

Uterine differentiation in cattle and sheep begins prenatally, but is completed postnatally. Mechanisms regulating this process are not well defined. However, studies of urogenital tract development in murine systems, particularly those involving tissue recombination and targeted gene mutation, indicate that the ideal uterine organizational programme evolves epigenetically through dynamic cell–cell and cell–matrix interactions that define the microenvironmental conte...

Somatic cell nuclear transfer (cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Nuclear transfer has potential applications in agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes (imprinted and X-linked genes) and global gene expression patterns in cloned bovine embryos/offspring as compared to those generate...

Summary. In cattle we have noted that the antral follicle count (AFC, follicles ≥3 mm in diameter) varies greatly among animals (from 5 to 50), is repeatable within animals, and is highly correlated with the total number of healthy follicles in ovaries. Also, animals with low AFC have higher serum concentrations of FSH and LH, but lower concentrations of Anti-Mullerian Hormone, progesterone and androgens than animals with high AFC. We have investigated t...